Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis

The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examine...

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Autores principales: Matakidou, A, el Galta, R, Rudd, M F, Webb, E L, Bridle, H, Eisen, T, Houlston, R S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359960/
https://www.ncbi.nlm.nih.gov/pubmed/17519899
http://dx.doi.org/10.1038/sj.bjc.6603816
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author Matakidou, A
el Galta, R
Rudd, M F
Webb, E L
Bridle, H
Eisen, T
Houlston, R S
author_facet Matakidou, A
el Galta, R
Rudd, M F
Webb, E L
Bridle, H
Eisen, T
Houlston, R S
author_sort Matakidou, A
collection PubMed
description The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
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spelling pubmed-23599602009-09-10 Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis Matakidou, A el Galta, R Rudd, M F Webb, E L Bridle, H Eisen, T Houlston, R S Br J Cancer Molecular Diagnostics The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis. Nature Publishing Group 2007-06-18 2007-05-22 /pmc/articles/PMC2359960/ /pubmed/17519899 http://dx.doi.org/10.1038/sj.bjc.6603816 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Matakidou, A
el Galta, R
Rudd, M F
Webb, E L
Bridle, H
Eisen, T
Houlston, R S
Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis
title Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis
title_full Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis
title_fullStr Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis
title_full_unstemmed Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis
title_short Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis
title_sort further observations on the relationship between the fgfr4 gly388arg polymorphism and lung cancer prognosis
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359960/
https://www.ncbi.nlm.nih.gov/pubmed/17519899
http://dx.doi.org/10.1038/sj.bjc.6603816
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