Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma

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BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1β mutations, (84% mutations involved chromophobe), suggesting a role for BHD a...

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Autores principales: Gad, S, Lefèvre, S H, Khoo, S K, Giraud, S, Vieillefond, A, Vasiliu, V, Ferlicot, S, Molinié, V, Denoux, Y, Thiounn, N, Chrétien, Y, Méjean, A, Zerbib, M, Benoît, G, Hervé, J M, Allègre, G, Bressac-de Paillerets, B, Teh, B T, Richard, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360004/
https://www.ncbi.nlm.nih.gov/pubmed/17133269
http://dx.doi.org/10.1038/sj.bjc.6603492
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author Gad, S
Lefèvre, S H
Khoo, S K
Giraud, S
Vieillefond, A
Vasiliu, V
Ferlicot, S
Molinié, V
Denoux, Y
Thiounn, N
Chrétien, Y
Méjean, A
Zerbib, M
Benoît, G
Hervé, J M
Allègre, G
Bressac-de Paillerets, B
Teh, B T
Richard, S
author_facet Gad, S
Lefèvre, S H
Khoo, S K
Giraud, S
Vieillefond, A
Vasiliu, V
Ferlicot, S
Molinié, V
Denoux, Y
Thiounn, N
Chrétien, Y
Méjean, A
Zerbib, M
Benoît, G
Hervé, J M
Allègre, G
Bressac-de Paillerets, B
Teh, B T
Richard, S
author_sort Gad, S
collection PubMed
description BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1β mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.
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spelling pubmed-23600042009-09-10 Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma Gad, S Lefèvre, S H Khoo, S K Giraud, S Vieillefond, A Vasiliu, V Ferlicot, S Molinié, V Denoux, Y Thiounn, N Chrétien, Y Méjean, A Zerbib, M Benoît, G Hervé, J M Allègre, G Bressac-de Paillerets, B Teh, B T Richard, S Br J Cancer Short Communication BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1β mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype. Nature Publishing Group 2007-01-29 2006-11-28 /pmc/articles/PMC2360004/ /pubmed/17133269 http://dx.doi.org/10.1038/sj.bjc.6603492 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Gad, S
Lefèvre, S H
Khoo, S K
Giraud, S
Vieillefond, A
Vasiliu, V
Ferlicot, S
Molinié, V
Denoux, Y
Thiounn, N
Chrétien, Y
Méjean, A
Zerbib, M
Benoît, G
Hervé, J M
Allègre, G
Bressac-de Paillerets, B
Teh, B T
Richard, S
Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
title Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
title_full Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
title_fullStr Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
title_full_unstemmed Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
title_short Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
title_sort mutations in bhd and tp53 genes, but not in hnf1β gene, in a large series of sporadic chromophobe renal cell carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360004/
https://www.ncbi.nlm.nih.gov/pubmed/17133269
http://dx.doi.org/10.1038/sj.bjc.6603492
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