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Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells

Oxaliplatin (OHP) is an anticancer agent that acts by formation of Platinum-DNA (Pt-DNA) adducts resulting in DNA-strand breaks and is used for the treatment of colorectal cancer. The pyrimidine analog trifluorothymidine (TFT) forms together with a thymidine phosphorylase inhibitor (TPI) the antican...

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Detalles Bibliográficos
Autores principales:	Temmink, O H, Hoebe, E K, van der Born, K, Ackland, S P, Fukushima, M, Peters, G J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360012/ https://www.ncbi.nlm.nih.gov/pubmed/17242697 http://dx.doi.org/10.1038/sj.bjc.6603549

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