Interleukin-6 gene amplification and shortened survival in glioblastoma patients

Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were s...

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Detalles Bibliográficos
Autores principales: Tchirkov, A, Khalil, T, Chautard, E, Mokhtari, K, Véronèse, L, Irthum, B, Vago, P, Kémény, J-L, Verrelle, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360031/
https://www.ncbi.nlm.nih.gov/pubmed/17224923
http://dx.doi.org/10.1038/sj.bjc.6603586
Descripción
Sumario:Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival.

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