Interleukin-6 gene amplification and shortened survival in glioblastoma patients

Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were s...

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Autores principales: Tchirkov, A, Khalil, T, Chautard, E, Mokhtari, K, Véronèse, L, Irthum, B, Vago, P, Kémény, J-L, Verrelle, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360031/
https://www.ncbi.nlm.nih.gov/pubmed/17224923
http://dx.doi.org/10.1038/sj.bjc.6603586
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author Tchirkov, A
Khalil, T
Chautard, E
Mokhtari, K
Véronèse, L
Irthum, B
Vago, P
Kémény, J-L
Verrelle, P
author_facet Tchirkov, A
Khalil, T
Chautard, E
Mokhtari, K
Véronèse, L
Irthum, B
Vago, P
Kémény, J-L
Verrelle, P
author_sort Tchirkov, A
collection PubMed
description Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival.
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spelling pubmed-23600312009-09-10 Interleukin-6 gene amplification and shortened survival in glioblastoma patients Tchirkov, A Khalil, T Chautard, E Mokhtari, K Véronèse, L Irthum, B Vago, P Kémény, J-L Verrelle, P Br J Cancer Molecular Diagnostics Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival. Nature Publishing Group 2007-02-12 2007-01-16 /pmc/articles/PMC2360031/ /pubmed/17224923 http://dx.doi.org/10.1038/sj.bjc.6603586 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Tchirkov, A
Khalil, T
Chautard, E
Mokhtari, K
Véronèse, L
Irthum, B
Vago, P
Kémény, J-L
Verrelle, P
Interleukin-6 gene amplification and shortened survival in glioblastoma patients
title Interleukin-6 gene amplification and shortened survival in glioblastoma patients
title_full Interleukin-6 gene amplification and shortened survival in glioblastoma patients
title_fullStr Interleukin-6 gene amplification and shortened survival in glioblastoma patients
title_full_unstemmed Interleukin-6 gene amplification and shortened survival in glioblastoma patients
title_short Interleukin-6 gene amplification and shortened survival in glioblastoma patients
title_sort interleukin-6 gene amplification and shortened survival in glioblastoma patients
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360031/
https://www.ncbi.nlm.nih.gov/pubmed/17224923
http://dx.doi.org/10.1038/sj.bjc.6603586
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