Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study

Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects...

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Autores principales: van den Brandt, P A, Smits, K M, Goldbohm, R A, Weijenberg, M P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360034/
https://www.ncbi.nlm.nih.gov/pubmed/17285123
http://dx.doi.org/10.1038/sj.bjc.6603577
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author van den Brandt, P A
Smits, K M
Goldbohm, R A
Weijenberg, M P
author_facet van den Brandt, P A
Smits, K M
Goldbohm, R A
Weijenberg, M P
author_sort van den Brandt, P A
collection PubMed
description Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.
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spelling pubmed-23600342009-09-10 Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study van den Brandt, P A Smits, K M Goldbohm, R A Weijenberg, M P Br J Cancer Epidemiology Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance. Nature Publishing Group 2007-02-12 2007-02-06 /pmc/articles/PMC2360034/ /pubmed/17285123 http://dx.doi.org/10.1038/sj.bjc.6603577 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
van den Brandt, P A
Smits, K M
Goldbohm, R A
Weijenberg, M P
Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
title Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
title_full Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
title_fullStr Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
title_full_unstemmed Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
title_short Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
title_sort magnesium intake and colorectal cancer risk in the netherlands cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360034/
https://www.ncbi.nlm.nih.gov/pubmed/17285123
http://dx.doi.org/10.1038/sj.bjc.6603577
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