The role of the VEGF-C/VEGFR-3 axis in cancer progression

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of...

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Autores principales: Su, J-L, Yen, C-J, Chen, P-S, Chuang, S-E, Hong, C-C, Kuo, I-H, Chen, H-Y, Hung, M-C, Kuo, M-L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360045/
https://www.ncbi.nlm.nih.gov/pubmed/17164762
http://dx.doi.org/10.1038/sj.bjc.6603487
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author Su, J-L
Yen, C-J
Chen, P-S
Chuang, S-E
Hong, C-C
Kuo, I-H
Chen, H-Y
Hung, M-C
Kuo, M-L
author_facet Su, J-L
Yen, C-J
Chen, P-S
Chuang, S-E
Hong, C-C
Kuo, I-H
Chen, H-Y
Hung, M-C
Kuo, M-L
author_sort Su, J-L
collection PubMed
description Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.
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spelling pubmed-23600452009-09-10 The role of the VEGF-C/VEGFR-3 axis in cancer progression Su, J-L Yen, C-J Chen, P-S Chuang, S-E Hong, C-C Kuo, I-H Chen, H-Y Hung, M-C Kuo, M-L Br J Cancer Minireview Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression. Nature Publishing Group 2007-02-26 2006-12-12 /pmc/articles/PMC2360045/ /pubmed/17164762 http://dx.doi.org/10.1038/sj.bjc.6603487 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Su, J-L
Yen, C-J
Chen, P-S
Chuang, S-E
Hong, C-C
Kuo, I-H
Chen, H-Y
Hung, M-C
Kuo, M-L
The role of the VEGF-C/VEGFR-3 axis in cancer progression
title The role of the VEGF-C/VEGFR-3 axis in cancer progression
title_full The role of the VEGF-C/VEGFR-3 axis in cancer progression
title_fullStr The role of the VEGF-C/VEGFR-3 axis in cancer progression
title_full_unstemmed The role of the VEGF-C/VEGFR-3 axis in cancer progression
title_short The role of the VEGF-C/VEGFR-3 axis in cancer progression
title_sort role of the vegf-c/vegfr-3 axis in cancer progression
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360045/
https://www.ncbi.nlm.nih.gov/pubmed/17164762
http://dx.doi.org/10.1038/sj.bjc.6603487
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