Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements...

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Detalles Bibliográficos
Autores principales: Dubois, L, Dresselaers, T, Landuyt, W, Paesmans, K, Mengesha, A, Wouters, B G, Hecke, P Van, Theys, J, Lambin, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360068/
https://www.ncbi.nlm.nih.gov/pubmed/17311022
http://dx.doi.org/10.1038/sj.bjc.6603624
Descripción
Sumario:The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.

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