Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression

The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements...

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Autores principales: Dubois, L, Dresselaers, T, Landuyt, W, Paesmans, K, Mengesha, A, Wouters, B G, Hecke, P Van, Theys, J, Lambin, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360068/
https://www.ncbi.nlm.nih.gov/pubmed/17311022
http://dx.doi.org/10.1038/sj.bjc.6603624
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author Dubois, L
Dresselaers, T
Landuyt, W
Paesmans, K
Mengesha, A
Wouters, B G
Hecke, P Van
Theys, J
Lambin, P
author_facet Dubois, L
Dresselaers, T
Landuyt, W
Paesmans, K
Mengesha, A
Wouters, B G
Hecke, P Van
Theys, J
Lambin, P
author_sort Dubois, L
collection PubMed
description The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.
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spelling pubmed-23600682009-09-10 Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression Dubois, L Dresselaers, T Landuyt, W Paesmans, K Mengesha, A Wouters, B G Hecke, P Van Theys, J Lambin, P Br J Cancer Translational Therapeutics The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring. Nature Publishing Group 2007-03-12 2007-02-20 /pmc/articles/PMC2360068/ /pubmed/17311022 http://dx.doi.org/10.1038/sj.bjc.6603624 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Translational Therapeutics
Dubois, L
Dresselaers, T
Landuyt, W
Paesmans, K
Mengesha, A
Wouters, B G
Hecke, P Van
Theys, J
Lambin, P
Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
title Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
title_full Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
title_fullStr Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
title_full_unstemmed Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
title_short Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
title_sort efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
topic Translational Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360068/
https://www.ncbi.nlm.nih.gov/pubmed/17311022
http://dx.doi.org/10.1038/sj.bjc.6603624
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