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A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360073/ https://www.ncbi.nlm.nih.gov/pubmed/17311018 http://dx.doi.org/10.1038/sj.bjc.6603629 |
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author | Kabat, G C Silvera, S A Navarro Miller, A B Rohan, T E |
author_facet | Kabat, G C Silvera, S A Navarro Miller, A B Rohan, T E |
author_sort | Kabat, G C |
collection | PubMed |
description | We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had ⩾5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR=2.41, 95% CI=1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal cell cancer, and that oral contraceptive use may be associated with reduced risk. |
format | Text |
id | pubmed-2360073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23600732009-09-10 A cohort study of reproductive and hormonal factors and renal cell cancer risk in women Kabat, G C Silvera, S A Navarro Miller, A B Rohan, T E Br J Cancer Epidemiology We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had ⩾5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR=2.41, 95% CI=1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal cell cancer, and that oral contraceptive use may be associated with reduced risk. Nature Publishing Group 2007-03-12 2007-02-20 /pmc/articles/PMC2360073/ /pubmed/17311018 http://dx.doi.org/10.1038/sj.bjc.6603629 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Kabat, G C Silvera, S A Navarro Miller, A B Rohan, T E A cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
title | A cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
title_full | A cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
title_fullStr | A cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
title_full_unstemmed | A cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
title_short | A cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
title_sort | cohort study of reproductive and hormonal factors and renal cell cancer risk in women |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360073/ https://www.ncbi.nlm.nih.gov/pubmed/17311018 http://dx.doi.org/10.1038/sj.bjc.6603629 |
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