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A cohort study of reproductive and hormonal factors and renal cell cancer risk in women

We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant...

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Autores principales: Kabat, G C, Silvera, S A Navarro, Miller, A B, Rohan, T E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360073/
https://www.ncbi.nlm.nih.gov/pubmed/17311018
http://dx.doi.org/10.1038/sj.bjc.6603629
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author Kabat, G C
Silvera, S A Navarro
Miller, A B
Rohan, T E
author_facet Kabat, G C
Silvera, S A Navarro
Miller, A B
Rohan, T E
author_sort Kabat, G C
collection PubMed
description We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had ⩾5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR=2.41, 95% CI=1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal cell cancer, and that oral contraceptive use may be associated with reduced risk.
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spelling pubmed-23600732009-09-10 A cohort study of reproductive and hormonal factors and renal cell cancer risk in women Kabat, G C Silvera, S A Navarro Miller, A B Rohan, T E Br J Cancer Epidemiology We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had ⩾5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR=2.41, 95% CI=1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal cell cancer, and that oral contraceptive use may be associated with reduced risk. Nature Publishing Group 2007-03-12 2007-02-20 /pmc/articles/PMC2360073/ /pubmed/17311018 http://dx.doi.org/10.1038/sj.bjc.6603629 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Kabat, G C
Silvera, S A Navarro
Miller, A B
Rohan, T E
A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
title A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
title_full A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
title_fullStr A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
title_full_unstemmed A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
title_short A cohort study of reproductive and hormonal factors and renal cell cancer risk in women
title_sort cohort study of reproductive and hormonal factors and renal cell cancer risk in women
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360073/
https://www.ncbi.nlm.nih.gov/pubmed/17311018
http://dx.doi.org/10.1038/sj.bjc.6603629
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