Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours

A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of...

Descripción completa

Detalles Bibliográficos
Autores principales: Salto-Tellez, M, Nga, M E, Han, H C, Wong, A S-C, Lee, C K, Anuar, D, Ng, S S, Ho, M, Wee, A, Chan, Y H, Soong, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360083/
https://www.ncbi.nlm.nih.gov/pubmed/17299397
http://dx.doi.org/10.1038/sj.bjc.6603551
Descripción
Sumario:A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants that may have functional significance.

Ejemplares similares