Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours

A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of...

Descripción completa

Detalles Bibliográficos
Autores principales: Salto-Tellez, M, Nga, M E, Han, H C, Wong, A S-C, Lee, C K, Anuar, D, Ng, S S, Ho, M, Wee, A, Chan, Y H, Soong, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360083/
https://www.ncbi.nlm.nih.gov/pubmed/17299397
http://dx.doi.org/10.1038/sj.bjc.6603551
_version_ 1782152959598002176
author Salto-Tellez, M
Nga, M E
Han, H C
Wong, A S-C
Lee, C K
Anuar, D
Ng, S S
Ho, M
Wee, A
Chan, Y H
Soong, R
author_facet Salto-Tellez, M
Nga, M E
Han, H C
Wong, A S-C
Lee, C K
Anuar, D
Ng, S S
Ho, M
Wee, A
Chan, Y H
Soong, R
author_sort Salto-Tellez, M
collection PubMed
description A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants that may have functional significance.
format Text
id pubmed-2360083
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23600832009-09-10 Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours Salto-Tellez, M Nga, M E Han, H C Wong, A S-C Lee, C K Anuar, D Ng, S S Ho, M Wee, A Chan, Y H Soong, R Br J Cancer Molecular Diagnostics A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants that may have functional significance. Nature Publishing Group 2007-03-12 2007-02-13 /pmc/articles/PMC2360083/ /pubmed/17299397 http://dx.doi.org/10.1038/sj.bjc.6603551 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Salto-Tellez, M
Nga, M E
Han, H C
Wong, A S-C
Lee, C K
Anuar, D
Ng, S S
Ho, M
Wee, A
Chan, Y H
Soong, R
Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
title Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
title_full Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
title_fullStr Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
title_full_unstemmed Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
title_short Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
title_sort tissue microarrays characterise the clinical significance of a vegf-a protein expression signature in gastrointestinal stromal tumours
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360083/
https://www.ncbi.nlm.nih.gov/pubmed/17299397
http://dx.doi.org/10.1038/sj.bjc.6603551
work_keys_str_mv AT saltotellezm tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT ngame tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT hanhc tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT wongasc tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT leeck tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT anuard tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT ngss tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT hom tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT weea tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT chanyh tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours
AT soongr tissuemicroarrayscharacterisetheclinicalsignificanceofavegfaproteinexpressionsignatureingastrointestinalstromaltumours

Ejemplares similares