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Interpretation of microarray data in cancer

Microarray studies aim at identifying homogeneous subtypes of cancer patients, searching for differentially expressed genes in tumours with different characteristics, or predicting the prognosis of patients. Using breast cancer as an example, we discuss the hypotheses underlying these studies, their...

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Detalles Bibliográficos
Autores principales: Michiels, S, Koscielny, S, Hill, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360153/
https://www.ncbi.nlm.nih.gov/pubmed/17342085
http://dx.doi.org/10.1038/sj.bjc.6603673
Descripción
Sumario:Microarray studies aim at identifying homogeneous subtypes of cancer patients, searching for differentially expressed genes in tumours with different characteristics, or predicting the prognosis of patients. Using breast cancer as an example, we discuss the hypotheses underlying these studies, their power, and the validity and the clinical usefulness of the findings.