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Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

Inactivation of the von Hippel–Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the α subunits of hypoxia-inducible factor (HIF), constitutive upregulation of the HIF complex, and overexpression of HIF target genes. However, recent studies have ind...

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Detalles Bibliográficos
Autores principales:	Lau, K W, Tian, Y-M, Raval, R R, Ratcliffe, P J, Pugh, C W
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360163/ https://www.ncbi.nlm.nih.gov/pubmed/17387348 http://dx.doi.org/10.1038/sj.bjc.6603675

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