Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study

We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring. Exposure to high-dose gonadal irradiation was not associated...

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Detalles Bibliográficos
Autores principales: Reulen, R C, Zeegers, M P, Lancashire, E R, Winter, D L, Hawkins, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360164/
https://www.ncbi.nlm.nih.gov/pubmed/17426701
http://dx.doi.org/10.1038/sj.bjc.6603736
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author Reulen, R C
Zeegers, M P
Lancashire, E R
Winter, D L
Hawkins, M M
author_facet Reulen, R C
Zeegers, M P
Lancashire, E R
Winter, D L
Hawkins, M M
author_sort Reulen, R C
collection PubMed
description We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring. Exposure to high-dose gonadal irradiation was not associated with a significant alteration in offspring sex ratio compared to low doses (men: P=0.58, women: P=0.66). There was also no evidence that the ratio varied with time since cancer diagnosis when comparing survivors treated with radiotherapy vs those without (men: P=0.51; women: P=0.46). This, the largest study to date, finds no evidence that exposure to radiation affects the offspring sex ratio among survivors of childhood cancer.
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spelling pubmed-23601642009-09-10 Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study Reulen, R C Zeegers, M P Lancashire, E R Winter, D L Hawkins, M M Br J Cancer Epidemiology We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring. Exposure to high-dose gonadal irradiation was not associated with a significant alteration in offspring sex ratio compared to low doses (men: P=0.58, women: P=0.66). There was also no evidence that the ratio varied with time since cancer diagnosis when comparing survivors treated with radiotherapy vs those without (men: P=0.51; women: P=0.46). This, the largest study to date, finds no evidence that exposure to radiation affects the offspring sex ratio among survivors of childhood cancer. Nature Publishing Group 2007-05-07 2007-04-10 /pmc/articles/PMC2360164/ /pubmed/17426701 http://dx.doi.org/10.1038/sj.bjc.6603736 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Reulen, R C
Zeegers, M P
Lancashire, E R
Winter, D L
Hawkins, M M
Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
title Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
title_full Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
title_fullStr Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
title_full_unstemmed Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
title_short Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study
title_sort offspring sex ratio and gonadal irradiation in the british childhood cancer survivor study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360164/
https://www.ncbi.nlm.nih.gov/pubmed/17426701
http://dx.doi.org/10.1038/sj.bjc.6603736
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