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Obesity and the risk of gallbladder cancer: a meta-analysis
We performed a meta-analysis of studies of the association between excess body weight and risk of gallbladder cancer identified from MEDLINE and EMBASE databases from 1966 to February 2007 and the references of retrieved articles. A random-effects model was used to combine results from eight cohort...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360167/ https://www.ncbi.nlm.nih.gov/pubmed/17375043 http://dx.doi.org/10.1038/sj.bjc.6603703 |
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author | Larsson, S C Wolk, A |
author_facet | Larsson, S C Wolk, A |
author_sort | Larsson, S C |
collection | PubMed |
description | We performed a meta-analysis of studies of the association between excess body weight and risk of gallbladder cancer identified from MEDLINE and EMBASE databases from 1966 to February 2007 and the references of retrieved articles. A random-effects model was used to combine results from eight cohort studies and three case–control studies, with a total of 3288 cases. Compared with individuals of ‘normal weight’, the summary relative risk of gallbladder cancer for those who were overweight or obese was 1.15 (95% CI, 1.01–1.30) and 1.66 (95% CI, 1.47–1.88) respectively. The association with obesity was stronger for women (relative risk, 1.88; 95% CI, 1.66–2.13) than for men (relative risk, 1.35; 95% CI, 1.09–1.68). There was no statistically significant heterogeneity among the results of individual studies. This meta-analysis confirms the association between excess body weight and risk of gallbladder cancer. |
format | Text |
id | pubmed-2360167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23601672009-09-10 Obesity and the risk of gallbladder cancer: a meta-analysis Larsson, S C Wolk, A Br J Cancer Epidemiology We performed a meta-analysis of studies of the association between excess body weight and risk of gallbladder cancer identified from MEDLINE and EMBASE databases from 1966 to February 2007 and the references of retrieved articles. A random-effects model was used to combine results from eight cohort studies and three case–control studies, with a total of 3288 cases. Compared with individuals of ‘normal weight’, the summary relative risk of gallbladder cancer for those who were overweight or obese was 1.15 (95% CI, 1.01–1.30) and 1.66 (95% CI, 1.47–1.88) respectively. The association with obesity was stronger for women (relative risk, 1.88; 95% CI, 1.66–2.13) than for men (relative risk, 1.35; 95% CI, 1.09–1.68). There was no statistically significant heterogeneity among the results of individual studies. This meta-analysis confirms the association between excess body weight and risk of gallbladder cancer. Nature Publishing Group 2007-05-07 2007-03-20 /pmc/articles/PMC2360167/ /pubmed/17375043 http://dx.doi.org/10.1038/sj.bjc.6603703 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Larsson, S C Wolk, A Obesity and the risk of gallbladder cancer: a meta-analysis |
title | Obesity and the risk of gallbladder cancer: a meta-analysis |
title_full | Obesity and the risk of gallbladder cancer: a meta-analysis |
title_fullStr | Obesity and the risk of gallbladder cancer: a meta-analysis |
title_full_unstemmed | Obesity and the risk of gallbladder cancer: a meta-analysis |
title_short | Obesity and the risk of gallbladder cancer: a meta-analysis |
title_sort | obesity and the risk of gallbladder cancer: a meta-analysis |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360167/ https://www.ncbi.nlm.nih.gov/pubmed/17375043 http://dx.doi.org/10.1038/sj.bjc.6603703 |
work_keys_str_mv | AT larssonsc obesityandtheriskofgallbladdercancerametaanalysis AT wolka obesityandtheriskofgallbladdercancerametaanalysis |