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Alcohol and head and neck cancer risk in a prospective study

We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2 203 500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent g...

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Autores principales: Freedman, N D, Schatzkin, A, Leitzmann, M F, Hollenbeck, A R, Abnet, C C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360181/
https://www.ncbi.nlm.nih.gov/pubmed/17387340
http://dx.doi.org/10.1038/sj.bjc.6603713
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author Freedman, N D
Schatzkin, A
Leitzmann, M F
Hollenbeck, A R
Abnet, C C
author_facet Freedman, N D
Schatzkin, A
Leitzmann, M F
Hollenbeck, A R
Abnet, C C
author_sort Freedman, N D
collection PubMed
description We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2 203 500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers showed an increased risk of head and neck cancer (men: hazard ratio (HR) 1.68, 95% confidence interval (95% CI) 1.37–2.06; women: 1.46, 1.02–2.08). Among male and female alcohol drinkers, we observed a significant dose–response relationship between alcohol consumption and risk. The HR for consuming >3 drinks per day was significantly higher in women (2.52, 1.46–4.35) than in men (1.48, 1.15–1.90; P for interaction=0.0036). The incidence rates per 100 000 person-years for those who consumed >3 drinks per day were similar in men (77.6) and women (75.3). The higher HRs observed in women resulted from lower incidence rates in the referent group: women (14.7), men (34.4). In summary, drinking >3 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk relative to non-drinking.
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spelling pubmed-23601812009-09-10 Alcohol and head and neck cancer risk in a prospective study Freedman, N D Schatzkin, A Leitzmann, M F Hollenbeck, A R Abnet, C C Br J Cancer Epidemiology We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2 203 500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers showed an increased risk of head and neck cancer (men: hazard ratio (HR) 1.68, 95% confidence interval (95% CI) 1.37–2.06; women: 1.46, 1.02–2.08). Among male and female alcohol drinkers, we observed a significant dose–response relationship between alcohol consumption and risk. The HR for consuming >3 drinks per day was significantly higher in women (2.52, 1.46–4.35) than in men (1.48, 1.15–1.90; P for interaction=0.0036). The incidence rates per 100 000 person-years for those who consumed >3 drinks per day were similar in men (77.6) and women (75.3). The higher HRs observed in women resulted from lower incidence rates in the referent group: women (14.7), men (34.4). In summary, drinking >3 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk relative to non-drinking. Nature Publishing Group 2007-05-07 2007-03-27 /pmc/articles/PMC2360181/ /pubmed/17387340 http://dx.doi.org/10.1038/sj.bjc.6603713 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Freedman, N D
Schatzkin, A
Leitzmann, M F
Hollenbeck, A R
Abnet, C C
Alcohol and head and neck cancer risk in a prospective study
title Alcohol and head and neck cancer risk in a prospective study
title_full Alcohol and head and neck cancer risk in a prospective study
title_fullStr Alcohol and head and neck cancer risk in a prospective study
title_full_unstemmed Alcohol and head and neck cancer risk in a prospective study
title_short Alcohol and head and neck cancer risk in a prospective study
title_sort alcohol and head and neck cancer risk in a prospective study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360181/
https://www.ncbi.nlm.nih.gov/pubmed/17387340
http://dx.doi.org/10.1038/sj.bjc.6603713
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