Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer

Virtually all cases of cervical cancer and its precursor intra-epithelial lesions are a result of infection with one or other of a subset of genital human papillomaviruses (HPVs), suggesting that prevention of HPV infection by prophylactic vaccination would be a highly effective anticancer strategy....

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Detalles Bibliográficos
Autor principal: Stanley, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360190/
https://www.ncbi.nlm.nih.gov/pubmed/17375045
http://dx.doi.org/10.1038/sj.bjc.6603695
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author Stanley, M
author_facet Stanley, M
author_sort Stanley, M
collection PubMed
description Virtually all cases of cervical cancer and its precursor intra-epithelial lesions are a result of infection with one or other of a subset of genital human papillomaviruses (HPVs), suggesting that prevention of HPV infection by prophylactic vaccination would be a highly effective anticancer strategy. Two HPV L1 virus-like particle vaccines have been developed, a quadrivalent HPV16/18/6/11 product and a bivalent HPV16/18 product; both have been shown to be highly immunogenic with a good safety profile and 100% efficacy against HPV16/18-related high-grade cervical intra-epithelial neoplasia (CIN2/3), implying that they will be effective at preventing HPV16/18-related cervical cancer.
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spelling pubmed-23601902009-09-10 Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer Stanley, M Br J Cancer Review Virtually all cases of cervical cancer and its precursor intra-epithelial lesions are a result of infection with one or other of a subset of genital human papillomaviruses (HPVs), suggesting that prevention of HPV infection by prophylactic vaccination would be a highly effective anticancer strategy. Two HPV L1 virus-like particle vaccines have been developed, a quadrivalent HPV16/18/6/11 product and a bivalent HPV16/18 product; both have been shown to be highly immunogenic with a good safety profile and 100% efficacy against HPV16/18-related high-grade cervical intra-epithelial neoplasia (CIN2/3), implying that they will be effective at preventing HPV16/18-related cervical cancer. Nature Publishing Group 2007-05-07 2007-03-20 /pmc/articles/PMC2360190/ /pubmed/17375045 http://dx.doi.org/10.1038/sj.bjc.6603695 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Stanley, M
Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
title Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
title_full Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
title_fullStr Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
title_full_unstemmed Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
title_short Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
title_sort prophylactic hpv vaccines: prospects for eliminating ano-genital cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360190/
https://www.ncbi.nlm.nih.gov/pubmed/17375045
http://dx.doi.org/10.1038/sj.bjc.6603695
work_keys_str_mv AT stanleym prophylactichpvvaccinesprospectsforeliminatinganogenitalcancer

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