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Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease and one of the cancer entities with the lowest life expectancy. Beside surgical therapy, no effective therapeutic options are available yet. Here, we show that 4-phenylbutyrate (4-PB), a known and well-tolerable inhibitor of histone deacetyl...

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Detalles Bibliográficos
Autores principales:	Ammerpohl, O, Trauzold, A, Schniewind, B, Griep, U, Pilarsky, C, Grutzmann, R, Saeger, H-D, Janssen, O, Sipos, B, Kloppel, G, Kalthoff, H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360208/ https://www.ncbi.nlm.nih.gov/pubmed/17164759 http://dx.doi.org/10.1038/sj.bjc.6603511

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