Stem cells of ependymoma

Ependymomas are tumours that arise throughout the central nervous system. Little is known regarding the aberrant cellular and molecular processes that generate these tumours. This lack of knowledge has hampered efforts to reduce the significant mortality and morbidity that are associated with ependy...

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Detalles Bibliográficos
Autores principales: Poppleton, H, Gilbertson, R J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360214/
https://www.ncbi.nlm.nih.gov/pubmed/17179988
http://dx.doi.org/10.1038/sj.bjc.6603519
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author Poppleton, H
Gilbertson, R J
author_facet Poppleton, H
Gilbertson, R J
author_sort Poppleton, H
collection PubMed
description Ependymomas are tumours that arise throughout the central nervous system. Little is known regarding the aberrant cellular and molecular processes that generate these tumours. This lack of knowledge has hampered efforts to reduce the significant mortality and morbidity that are associated with ependymoma. Here, we review recent data that suggest that radial glia are cells of origin of ependymoma, and discuss the processes that might transform these neural progenitors into ependymoma cancer stem cells.
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spelling pubmed-23602142009-09-10 Stem cells of ependymoma Poppleton, H Gilbertson, R J Br J Cancer Minireview Ependymomas are tumours that arise throughout the central nervous system. Little is known regarding the aberrant cellular and molecular processes that generate these tumours. This lack of knowledge has hampered efforts to reduce the significant mortality and morbidity that are associated with ependymoma. Here, we review recent data that suggest that radial glia are cells of origin of ependymoma, and discuss the processes that might transform these neural progenitors into ependymoma cancer stem cells. Nature Publishing Group 2007-01-15 2006-12-19 /pmc/articles/PMC2360214/ /pubmed/17179988 http://dx.doi.org/10.1038/sj.bjc.6603519 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Poppleton, H
Gilbertson, R J
Stem cells of ependymoma
title Stem cells of ependymoma
title_full Stem cells of ependymoma
title_fullStr Stem cells of ependymoma
title_full_unstemmed Stem cells of ependymoma
title_short Stem cells of ependymoma
title_sort stem cells of ependymoma
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360214/
https://www.ncbi.nlm.nih.gov/pubmed/17179988
http://dx.doi.org/10.1038/sj.bjc.6603519
work_keys_str_mv AT poppletonh stemcellsofependymoma
AT gilbertsonrj stemcellsofependymoma

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