Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features

Activation of RAS signalling induced by K-ras/BRAF mutations is a hallmark of colorectal tumours. In addition, Ras association domain families 1 and 2 (RASSF1 and RASSF2), the negative regulators of K-ras, are often inactivated by methylation of the promoter region in those tumours. However, reports...

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Detalles Bibliográficos
Autores principales: Harada, K, Hiraoka, S, Kato, J, Horii, J, Fujita, H, Sakaguchi, K, Shiratori, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360240/
https://www.ncbi.nlm.nih.gov/pubmed/17923875
http://dx.doi.org/10.1038/sj.bjc.6604014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360240/
https://www.ncbi.nlm.nih.gov/pubmed/17923875
http://dx.doi.org/10.1038/sj.bjc.6604014

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