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COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia

Morphine and its congener opioids are the main therapy for severe pain in cancer. However, chronic morphine treatment stimulates angiogenesis and tumour growth in mice. We examined if celecoxib (a cyclooxygenase-2 (COX-2) inhibitor) prevents morphine-induced tumour growth without compromising analge...

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Detalles Bibliográficos
Autores principales:	Farooqui, M, Li, Y, Rogers, T, Poonawala, T, Griffin, R J, Song, C W, Gupta, K
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360252/ https://www.ncbi.nlm.nih.gov/pubmed/17971769 http://dx.doi.org/10.1038/sj.bjc.6604057

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