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A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies

Canonical Wnt signalling is an osteoinductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt signalling and thus inhibits osteogenesis. To examine a potential osteoinhibitory role of Dkk-1 in osteosar...

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Detalles Bibliográficos
Autores principales:	Lee, N, Smolarz, A J, Olson, S, David, O, Reiser, J, Kutner, R, Daw, N C, Prockop, D J, Horwitz, E M, Gregory, C A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360262/ https://www.ncbi.nlm.nih.gov/pubmed/17987039 http://dx.doi.org/10.1038/sj.bjc.6604069

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