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OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome

Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explore...

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Autores principales: Staibano, S, Merolla, F, Testa, D, Iovine, R, Mascolo, M, Guarino, V, Castellone, M D, Di Benedetto, M, Galli, V, Motta, S, Melillo, R M, De Rosa, G, Santoro, M, Celetti, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360266/
https://www.ncbi.nlm.nih.gov/pubmed/17987038
http://dx.doi.org/10.1038/sj.bjc.6604070
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author Staibano, S
Merolla, F
Testa, D
Iovine, R
Mascolo, M
Guarino, V
Castellone, M D
Di Benedetto, M
Galli, V
Motta, S
Melillo, R M
De Rosa, G
Santoro, M
Celetti, A
author_facet Staibano, S
Merolla, F
Testa, D
Iovine, R
Mascolo, M
Guarino, V
Castellone, M D
Di Benedetto, M
Galli, V
Motta, S
Melillo, R M
De Rosa, G
Santoro, M
Celetti, A
author_sort Staibano, S
collection PubMed
description Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explored OPN as a candidate biomarker for laryngeal dysplasia. To this aim, we examined OPN expression in 82 cases of dysplasia and in hyperplastic and normal tissue samples. OPN expression was elevated in all severe dysplasia samples, but not hyperplastic samples, with respect to matched normal mucosa. OPN expression levels correlated positively with degree of dysplasia (P=0.0094) and negatively with disease-free survival (P<0.0001). OPN expression was paralleled by cell surface reactivity for CD44v6, an OPN functional receptor. CD44v6 expression correlated negatively with disease-free survival, as well (P=0.0007). Taken as a whole, our finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia.
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spelling pubmed-23602662009-09-10 OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome Staibano, S Merolla, F Testa, D Iovine, R Mascolo, M Guarino, V Castellone, M D Di Benedetto, M Galli, V Motta, S Melillo, R M De Rosa, G Santoro, M Celetti, A Br J Cancer Molecular Diagnostics Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explored OPN as a candidate biomarker for laryngeal dysplasia. To this aim, we examined OPN expression in 82 cases of dysplasia and in hyperplastic and normal tissue samples. OPN expression was elevated in all severe dysplasia samples, but not hyperplastic samples, with respect to matched normal mucosa. OPN expression levels correlated positively with degree of dysplasia (P=0.0094) and negatively with disease-free survival (P<0.0001). OPN expression was paralleled by cell surface reactivity for CD44v6, an OPN functional receptor. CD44v6 expression correlated negatively with disease-free survival, as well (P=0.0007). Taken as a whole, our finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia. Nature Publishing Group 2007-12-03 2007-11-06 /pmc/articles/PMC2360266/ /pubmed/17987038 http://dx.doi.org/10.1038/sj.bjc.6604070 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Staibano, S
Merolla, F
Testa, D
Iovine, R
Mascolo, M
Guarino, V
Castellone, M D
Di Benedetto, M
Galli, V
Motta, S
Melillo, R M
De Rosa, G
Santoro, M
Celetti, A
OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
title OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
title_full OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
title_fullStr OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
title_full_unstemmed OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
title_short OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
title_sort opn/cd44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360266/
https://www.ncbi.nlm.nih.gov/pubmed/17987038
http://dx.doi.org/10.1038/sj.bjc.6604070
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