Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy

Celecoxib (Celebrex®) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this compound harbours additional pharmacologic activities that are entirely independent of its COX-2-inhibitory activity. This review presents the re...

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Detalles Bibliográficos
Autor principal: Schönthal, A H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360267/
https://www.ncbi.nlm.nih.gov/pubmed/17955049
http://dx.doi.org/10.1038/sj.bjc.6604049
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author Schönthal, A H
author_facet Schönthal, A H
author_sort Schönthal, A H
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description Celecoxib (Celebrex®) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this compound harbours additional pharmacologic activities that are entirely independent of its COX-2-inhibitory activity. This review presents the recently emerged direct non-COX-2 targets of celecoxib and their proposed role in mediating this drug's antitumour effects.
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spelling pubmed-23602672009-09-10 Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy Schönthal, A H Br J Cancer Minireview Celecoxib (Celebrex®) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this compound harbours additional pharmacologic activities that are entirely independent of its COX-2-inhibitory activity. This review presents the recently emerged direct non-COX-2 targets of celecoxib and their proposed role in mediating this drug's antitumour effects. Nature Publishing Group 2007-12-03 2007-10-23 /pmc/articles/PMC2360267/ /pubmed/17955049 http://dx.doi.org/10.1038/sj.bjc.6604049 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Schönthal, A H
Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
title Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
title_full Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
title_fullStr Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
title_full_unstemmed Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
title_short Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
title_sort direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360267/
https://www.ncbi.nlm.nih.gov/pubmed/17955049
http://dx.doi.org/10.1038/sj.bjc.6604049
work_keys_str_mv AT schonthalah directnoncyclooxygenase2targetsofcelecoxibandtheirpotentialrelevanceforcancertherapy

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