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Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
Celecoxib (Celebrex®) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this compound harbours additional pharmacologic activities that are entirely independent of its COX-2-inhibitory activity. This review presents the re...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360267/ https://www.ncbi.nlm.nih.gov/pubmed/17955049 http://dx.doi.org/10.1038/sj.bjc.6604049 |
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author | Schönthal, A H |
author_facet | Schönthal, A H |
author_sort | Schönthal, A H |
collection | PubMed |
description | Celecoxib (Celebrex®) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this compound harbours additional pharmacologic activities that are entirely independent of its COX-2-inhibitory activity. This review presents the recently emerged direct non-COX-2 targets of celecoxib and their proposed role in mediating this drug's antitumour effects. |
format | Text |
id | pubmed-2360267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23602672009-09-10 Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy Schönthal, A H Br J Cancer Minireview Celecoxib (Celebrex®) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this compound harbours additional pharmacologic activities that are entirely independent of its COX-2-inhibitory activity. This review presents the recently emerged direct non-COX-2 targets of celecoxib and their proposed role in mediating this drug's antitumour effects. Nature Publishing Group 2007-12-03 2007-10-23 /pmc/articles/PMC2360267/ /pubmed/17955049 http://dx.doi.org/10.1038/sj.bjc.6604049 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Minireview Schönthal, A H Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
title | Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
title_full | Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
title_fullStr | Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
title_full_unstemmed | Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
title_short | Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
title_sort | direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360267/ https://www.ncbi.nlm.nih.gov/pubmed/17955049 http://dx.doi.org/10.1038/sj.bjc.6604049 |
work_keys_str_mv | AT schonthalah directnoncyclooxygenase2targetsofcelecoxibandtheirpotentialrelevanceforcancertherapy |