Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells

In this study, we set out to establish whether fludarabine could enhance the DNA interstrand crosslinking capacity of SJG-136 in primary human chronic lymphocytic leukaemia (CLL) cells and thereby offer a rationale for its clinical use in combination with SJG-136. SJG-136 rapidly induced DNA crossli...

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Detalles Bibliográficos
Autores principales: Pepper, C, Lowe, H, Fegan, C, Thurieau, C, Thurston, D E, Hartley, J A, Delavault, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360304/
https://www.ncbi.nlm.nih.gov/pubmed/17579621
http://dx.doi.org/10.1038/sj.bjc.6603853

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