Irradiation of rat brain reduces P-glycoprotein expression and function

The blood–brain barrier (BBB) hampers delivery of several drugs including chemotherapeutics to the brain. The drug efflux pump P-glycoprotein (P-gp), expressed on brain capillary endothelial cells, is part of the BBB. P-gp expression on capillary endothelium decreases 5 days after brain irradiation,...

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Detalles Bibliográficos
Autores principales: Bart, J, Nagengast, W B, Coppes, R P, Wegman, T D, van der Graaf, W T A, Groen, H J M, Vaalburg, W, de Vries, E G E, Hendrikse, N H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360314/
https://www.ncbi.nlm.nih.gov/pubmed/17609666
http://dx.doi.org/10.1038/sj.bjc.6603864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360314/
https://www.ncbi.nlm.nih.gov/pubmed/17609666
http://dx.doi.org/10.1038/sj.bjc.6603864

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