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Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are necessary but not sufficient to produce invasive breast cancer because intraductal tumour growth is al...

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Detalles Bibliográficos
Autores principales:	Gatenby, R A, Smallbone, K, Maini, P K, Rose, F, Averill, J, Nagle, R B, Worrall, L, Gillies, R J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360372/ https://www.ncbi.nlm.nih.gov/pubmed/17687336 http://dx.doi.org/10.1038/sj.bjc.6603922

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