Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified...

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Detalles Bibliográficos
Autores principales: Larsson, S C, Wolk, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360408/
https://www.ncbi.nlm.nih.gov/pubmed/17700568
http://dx.doi.org/10.1038/sj.bjc.6603932
Descripción
Sumario:Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02–1.34) for those who were overweight and 1.89 (95% CI: 1.51–2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer.

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