Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified...

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Autores principales: Larsson, S C, Wolk, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360408/
https://www.ncbi.nlm.nih.gov/pubmed/17700568
http://dx.doi.org/10.1038/sj.bjc.6603932
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author Larsson, S C
Wolk, A
author_facet Larsson, S C
Wolk, A
author_sort Larsson, S C
collection PubMed
description Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02–1.34) for those who were overweight and 1.89 (95% CI: 1.51–2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer.
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spelling pubmed-23604082009-09-10 Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies Larsson, S C Wolk, A Br J Cancer Epidemiology Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02–1.34) for those who were overweight and 1.89 (95% CI: 1.51–2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer. Nature Publishing Group 2007-10-08 2007-08-14 /pmc/articles/PMC2360408/ /pubmed/17700568 http://dx.doi.org/10.1038/sj.bjc.6603932 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Larsson, S C
Wolk, A
Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
title Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
title_full Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
title_fullStr Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
title_full_unstemmed Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
title_short Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
title_sort overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360408/
https://www.ncbi.nlm.nih.gov/pubmed/17700568
http://dx.doi.org/10.1038/sj.bjc.6603932
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