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Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer
The purpose of this study is to investigate the associations of microvessel density (MVD) and other pathological variables with survival, and whether they accounted for survival differences between Japanese and British patients. One hundred seventy-three Japanese and 184 British patients were includ...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360458/ https://www.ncbi.nlm.nih.gov/pubmed/17923874 http://dx.doi.org/10.1038/sj.bjc.6604015 |
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author | Kato, T Steers, G Campo, L Roberts, H Leek, R D Turley, H Kimura, T Kameoka, S Nishikawa, T Kobayashi, M Harris, A L Gatter, K C Pezzella, F |
author_facet | Kato, T Steers, G Campo, L Roberts, H Leek, R D Turley, H Kimura, T Kameoka, S Nishikawa, T Kobayashi, M Harris, A L Gatter, K C Pezzella, F |
author_sort | Kato, T |
collection | PubMed |
description | The purpose of this study is to investigate the associations of microvessel density (MVD) and other pathological variables with survival, and whether they accounted for survival differences between Japanese and British patients. One hundred seventy-three Japanese and 184 British patients were included in the study. British patients were significantly older (56.3±11.4 years vs 52.5±12.9 years; P<0.01) and had smaller tumours (2.2±1.3 vs 2.7±1.8 cm; P<0.01), which were more frequently oestrogen receptor positive (78.8 vs 57.2%, P<0.01), had more grade III tumours (29.9 vs 21.4%, P=0.04) and more infiltrating lobular carcinomas (13.6 vs 4.0%, P<0.01) and a higher MVD compared with Japanese patients (57.9±19.8 vs 53.2±18.6; P=0.01). However, no difference in the prevalence of lymph-node metastasis was found between them (39.1 vs 37.5%, P=0.75). Younger British patients (age <50 years) had the highest MVD compared with Japanese and older British patients (P<0.01). Japanese patients were proportionately more likely to receive chemotherapy than endocrine therapy (P<0.01). British patients had a significantly worse relapse-free survival and overall survival compared with Japanese patients, after statistical adjustment for variables (hazard ratio=2.1, 2.4, P<0.01, P<0.01, respectively), especially, in T2 stage, low MVD and older subgroup (HR: 3.6, 5.0; 3.1, 3.3; 3.2, 3.9, respectively), but only in ER negative cases (P=0.04, P=0.01, respectively). The present study shows that MVD contributes to the Japanese–British disparity in breast cancer. However, the MVD variability did not explain the survival differences between Japanese and British patients. |
format | Text |
id | pubmed-2360458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23604582009-09-10 Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer Kato, T Steers, G Campo, L Roberts, H Leek, R D Turley, H Kimura, T Kameoka, S Nishikawa, T Kobayashi, M Harris, A L Gatter, K C Pezzella, F Br J Cancer Molecular Diagnostics The purpose of this study is to investigate the associations of microvessel density (MVD) and other pathological variables with survival, and whether they accounted for survival differences between Japanese and British patients. One hundred seventy-three Japanese and 184 British patients were included in the study. British patients were significantly older (56.3±11.4 years vs 52.5±12.9 years; P<0.01) and had smaller tumours (2.2±1.3 vs 2.7±1.8 cm; P<0.01), which were more frequently oestrogen receptor positive (78.8 vs 57.2%, P<0.01), had more grade III tumours (29.9 vs 21.4%, P=0.04) and more infiltrating lobular carcinomas (13.6 vs 4.0%, P<0.01) and a higher MVD compared with Japanese patients (57.9±19.8 vs 53.2±18.6; P=0.01). However, no difference in the prevalence of lymph-node metastasis was found between them (39.1 vs 37.5%, P=0.75). Younger British patients (age <50 years) had the highest MVD compared with Japanese and older British patients (P<0.01). Japanese patients were proportionately more likely to receive chemotherapy than endocrine therapy (P<0.01). British patients had a significantly worse relapse-free survival and overall survival compared with Japanese patients, after statistical adjustment for variables (hazard ratio=2.1, 2.4, P<0.01, P<0.01, respectively), especially, in T2 stage, low MVD and older subgroup (HR: 3.6, 5.0; 3.1, 3.3; 3.2, 3.9, respectively), but only in ER negative cases (P=0.04, P=0.01, respectively). The present study shows that MVD contributes to the Japanese–British disparity in breast cancer. However, the MVD variability did not explain the survival differences between Japanese and British patients. Nature Publishing Group 2007-11-05 2007-10-09 /pmc/articles/PMC2360458/ /pubmed/17923874 http://dx.doi.org/10.1038/sj.bjc.6604015 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Molecular Diagnostics Kato, T Steers, G Campo, L Roberts, H Leek, R D Turley, H Kimura, T Kameoka, S Nishikawa, T Kobayashi, M Harris, A L Gatter, K C Pezzella, F Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer |
title | Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer |
title_full | Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer |
title_fullStr | Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer |
title_full_unstemmed | Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer |
title_short | Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer |
title_sort | prognostic significance of microvessel density and other variables in japanese and british patients with primary invasive breast cancer |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360458/ https://www.ncbi.nlm.nih.gov/pubmed/17923874 http://dx.doi.org/10.1038/sj.bjc.6604015 |
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