Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F

Thymidylate synthase (TS) is the enzyme that catalyses the last step in de novo thymidylate synthesis. It is of interest clinically because it is an effective target for drugs such as 5-fluorouracil, often used in combination therapy. Despite a number of earlier reports indicating that TS is a cell...

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Detalles Bibliográficos
Autores principales: Le François, B G, Maroun, J A, Birnboim, H C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360461/
https://www.ncbi.nlm.nih.gov/pubmed/17923872
http://dx.doi.org/10.1038/sj.bjc.6604020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360461/
https://www.ncbi.nlm.nih.gov/pubmed/17923872
http://dx.doi.org/10.1038/sj.bjc.6604020

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