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Relationships between stem cell exhaustion, tumour suppression and ageing
Ageing is a complex process characterised by a variety of disorders associated with general organismal decline and an inability to maintain tissue homoeostasis. As described in this review, recent studies indicate that ageing may be caused, in part, by the depletion of stem and progenitor cells that...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360465/ https://www.ncbi.nlm.nih.gov/pubmed/17923865 http://dx.doi.org/10.1038/sj.bjc.6604029 |
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author | Ruzankina, Y Brown, E J |
author_facet | Ruzankina, Y Brown, E J |
author_sort | Ruzankina, Y |
collection | PubMed |
description | Ageing is a complex process characterised by a variety of disorders associated with general organismal decline and an inability to maintain tissue homoeostasis. As described in this review, recent studies indicate that ageing may be caused, in part, by the depletion of stem and progenitor cells that govern tissue renewal. The potential causes of stem and progenitor cell attrition are numerous; however, a commonly accepted theory is that these cells are lost as a result of naturally occurring DNA damage and the obligate checkpoint responses that follow. Failure to launch appropriate responses to DNA damage is strongly associated with cancer initiation and progression. Therefore, it is at this nexus, the response to DNA damage, that an important organismal fate may be determined: to degrade regenerative potential for the purpose of preventing cancer. According to this viewpoint, ageing may be the unfortunate mark of successful cancer suppression in stem cells and other cell types. In this review, we will describe how degeneration of tissue renewal capacity links ageing and cancer suppression. |
format | Text |
id | pubmed-2360465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23604652009-09-10 Relationships between stem cell exhaustion, tumour suppression and ageing Ruzankina, Y Brown, E J Br J Cancer Minireview Ageing is a complex process characterised by a variety of disorders associated with general organismal decline and an inability to maintain tissue homoeostasis. As described in this review, recent studies indicate that ageing may be caused, in part, by the depletion of stem and progenitor cells that govern tissue renewal. The potential causes of stem and progenitor cell attrition are numerous; however, a commonly accepted theory is that these cells are lost as a result of naturally occurring DNA damage and the obligate checkpoint responses that follow. Failure to launch appropriate responses to DNA damage is strongly associated with cancer initiation and progression. Therefore, it is at this nexus, the response to DNA damage, that an important organismal fate may be determined: to degrade regenerative potential for the purpose of preventing cancer. According to this viewpoint, ageing may be the unfortunate mark of successful cancer suppression in stem cells and other cell types. In this review, we will describe how degeneration of tissue renewal capacity links ageing and cancer suppression. Nature Publishing Group 2007-11-05 2007-10-09 /pmc/articles/PMC2360465/ /pubmed/17923865 http://dx.doi.org/10.1038/sj.bjc.6604029 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Minireview Ruzankina, Y Brown, E J Relationships between stem cell exhaustion, tumour suppression and ageing |
title | Relationships between stem cell exhaustion, tumour suppression and ageing |
title_full | Relationships between stem cell exhaustion, tumour suppression and ageing |
title_fullStr | Relationships between stem cell exhaustion, tumour suppression and ageing |
title_full_unstemmed | Relationships between stem cell exhaustion, tumour suppression and ageing |
title_short | Relationships between stem cell exhaustion, tumour suppression and ageing |
title_sort | relationships between stem cell exhaustion, tumour suppression and ageing |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360465/ https://www.ncbi.nlm.nih.gov/pubmed/17923865 http://dx.doi.org/10.1038/sj.bjc.6604029 |
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