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National study of colorectal cancer genetics

Approximately, a third of all colorectal cancer (CRC) is due to inherited susceptibility. However, high-risk mutations in APC, the mismatch repair (MMR) genes, MUTYH/MYH, SMAD4, ALK3 and STK11/LKB1 are rare and account for <5% of cases. Much of the remaining variation in genetic risk is likely to...

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Detalles Bibliográficos
Autores principales:	Penegar, S, Wood, W, Lubbe, S, Chandler, I, Broderick, P, Papaemmanuil, E, Sellick, G, Gray, R, Peto, J, Houlston, R
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Epidemiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360468/ https://www.ncbi.nlm.nih.gov/pubmed/17895893 http://dx.doi.org/10.1038/sj.bjc.6603997

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