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Temozolomide induces senescence but not apoptosis in human melanoma cells

Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA. Resistance to the agent may be in part due to the activity of O(6)-methylguanine-DNA methyl transferase (MGMT). In the...

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Detalles Bibliográficos
Autores principales:	Mhaidat, N M, Zhang, X D, Allen, J, Avery-Kiejda, K A, Scott, R J, Hersey, P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360470/ https://www.ncbi.nlm.nih.gov/pubmed/17968428 http://dx.doi.org/10.1038/sj.bjc.6604017

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