HIF-1 and tumour radiosensitivity

Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe cli...

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Detalles Bibliográficos
Autores principales: Moeller, B J, Dewhirst, M W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360497/
https://www.ncbi.nlm.nih.gov/pubmed/16735998
http://dx.doi.org/10.1038/sj.bjc.6603201
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author Moeller, B J
Dewhirst, M W
author_facet Moeller, B J
Dewhirst, M W
author_sort Moeller, B J
collection PubMed
description Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.
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spelling pubmed-23604972009-09-10 HIF-1 and tumour radiosensitivity Moeller, B J Dewhirst, M W Br J Cancer Minireview Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity. Nature Publishing Group 2006-07-03 2006-05-30 /pmc/articles/PMC2360497/ /pubmed/16735998 http://dx.doi.org/10.1038/sj.bjc.6603201 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Moeller, B J
Dewhirst, M W
HIF-1 and tumour radiosensitivity
title HIF-1 and tumour radiosensitivity
title_full HIF-1 and tumour radiosensitivity
title_fullStr HIF-1 and tumour radiosensitivity
title_full_unstemmed HIF-1 and tumour radiosensitivity
title_short HIF-1 and tumour radiosensitivity
title_sort hif-1 and tumour radiosensitivity
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360497/
https://www.ncbi.nlm.nih.gov/pubmed/16735998
http://dx.doi.org/10.1038/sj.bjc.6603201
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