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Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut

Pyrrolidinedithiocarbamate (PDTC) enhanced the activity of 5-fluorouracil (5-FU) in a colorectal cancer xenograft model. Pyrrolidinedithiocarbamate also reduced gastrointestinal toxicity associated with 5-FU therapy in large but not small bowel. We sought to clarify the basis of this differential en...

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Detalles Bibliográficos
Autores principales:	Bach, S P, Williamson, S E, O'Dwyer, S T, Potten, C S, Watson, A J M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2006
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360501/ https://www.ncbi.nlm.nih.gov/pubmed/16804527 http://dx.doi.org/10.1038/sj.bjc.6603224

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