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Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer

Paclitaxel is an important chemotherapeutic agent for breast cancer. Paclitaxel has high affinity for the P-glycoprotein (P-gp) (drug efflux pump) in the gastrointestinal tract causing low and variable oral bioavailability. Previously, we demonstrated that oral paclitaxel plus the P-gp inhibitor cic...

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Detalles Bibliográficos
Autores principales:	Helgason, H H, Kruijtzer, C M F, Huitema, A D R, Marcus, S G, ten Bokkel Huinink, W W, Schot, M E, Schornagel, J H, Beijnen, J H, Schellens, J H M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2006
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360545/ https://www.ncbi.nlm.nih.gov/pubmed/16969354 http://dx.doi.org/10.1038/sj.bjc.6603332

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