The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study

Midostaurin (PKC412A), N-benzoyl-staurosporine, potently inhibits protein kinase C alpha (PKCα), VEGFR2, KIT, PDGFR and FLT3 tyrosine kinases. In mice, midostaurin slows growth and delays lung metastasis of melanoma cell lines. We aimed to test midostaurin's safety, efficacy and biologic activi...

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Detalles Bibliográficos
Autores principales: Millward, M J, House, C, Bowtell, D, Webster, L, Olver, I N, Gore, M, Copeman, M, Lynch, K, Yap, A, Wang, Y, Cohen, P S, Zalcberg, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360547/
https://www.ncbi.nlm.nih.gov/pubmed/16969355
http://dx.doi.org/10.1038/sj.bjc.6603331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360547/
https://www.ncbi.nlm.nih.gov/pubmed/16969355
http://dx.doi.org/10.1038/sj.bjc.6603331

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