Mathematical models of targeted cancer therapy

Improved understanding of the molecular underpinnings of cancer initiation and progression has led to the development of targeted cancer therapies. The importance of these new methods of cancer treatment necessitates further research into the dynamic interactions between cancer cells and therapeutic...

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Detalles Bibliográficos
Autores principales: Abbott, L H, Michor, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360553/
https://www.ncbi.nlm.nih.gov/pubmed/17031409
http://dx.doi.org/10.1038/sj.bjc.6603310
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author Abbott, L H
Michor, F
author_facet Abbott, L H
Michor, F
author_sort Abbott, L H
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description Improved understanding of the molecular underpinnings of cancer initiation and progression has led to the development of targeted cancer therapies. The importance of these new methods of cancer treatment necessitates further research into the dynamic interactions between cancer cells and therapeutic agents, as well as a means of analysing their relationship quantitatively. The present review outlines the application of mathematical modelling to the dynamics of targeted cancer therapy, focusing particular attention on chronic myeloid leukaemia and its treatment with imatinib (Glivec).
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spelling pubmed-23605532009-09-10 Mathematical models of targeted cancer therapy Abbott, L H Michor, F Br J Cancer Minireview Improved understanding of the molecular underpinnings of cancer initiation and progression has led to the development of targeted cancer therapies. The importance of these new methods of cancer treatment necessitates further research into the dynamic interactions between cancer cells and therapeutic agents, as well as a means of analysing their relationship quantitatively. The present review outlines the application of mathematical modelling to the dynamics of targeted cancer therapy, focusing particular attention on chronic myeloid leukaemia and its treatment with imatinib (Glivec). Nature Publishing Group 2006-11-06 2006-10-10 /pmc/articles/PMC2360553/ /pubmed/17031409 http://dx.doi.org/10.1038/sj.bjc.6603310 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Abbott, L H
Michor, F
Mathematical models of targeted cancer therapy
title Mathematical models of targeted cancer therapy
title_full Mathematical models of targeted cancer therapy
title_fullStr Mathematical models of targeted cancer therapy
title_full_unstemmed Mathematical models of targeted cancer therapy
title_short Mathematical models of targeted cancer therapy
title_sort mathematical models of targeted cancer therapy
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360553/
https://www.ncbi.nlm.nih.gov/pubmed/17031409
http://dx.doi.org/10.1038/sj.bjc.6603310
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