Cargando…
Lung cancer risk among German male uranium miners: a cohort study, 1946–1998
From 1946 to 1990 extensive uranium mining was conducted in the southern parts of the former German Democratic Republic. The overall workforce included several 100 000 individuals. A cohort of 59 001 former male employees of the Wismut Company was established, forming a large retrospective uranium m...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360564/ https://www.ncbi.nlm.nih.gov/pubmed/17043686 http://dx.doi.org/10.1038/sj.bjc.6603403 |
_version_ | 1782153080764104704 |
---|---|
author | Grosche, B Kreuzer, M Kreisheimer, M Schnelzer, M Tschense, A |
author_facet | Grosche, B Kreuzer, M Kreisheimer, M Schnelzer, M Tschense, A |
author_sort | Grosche, B |
collection | PubMed |
description | From 1946 to 1990 extensive uranium mining was conducted in the southern parts of the former German Democratic Republic. The overall workforce included several 100 000 individuals. A cohort of 59 001 former male employees of the Wismut Company was established, forming a large retrospective uranium miners' cohort for the time period 1946–1998. Mean duration of follow-up was 30.5 years with a total of 1 801 630 person-years. Loss to follow-up was low at 5.3%. Of the workers, 16 598 (28.1%) died during the study period. Based on 2388 lung cancer deaths, the radon-related lung cancer risk is evaluated. The excess relative risk (ERR) per working level month (WLM) was estimated as 0.21% (95% CI: 0.18–0.24). It was dependent on time since exposure and on attained age. The highest ERR/WLM was observed 15–24 years after exposure and in the youngest age group (<55 years of age). While a strong inverse exposure-rate effect was detected for high exposures, no significant association was detected at exposures below 100 WLM. Excess relative risk /WLM was not modified by duration of exposure. The results would indicate the need to re-estimate the effects of risk modifying factors in current risk models as duration of exposure did not modify the ERR/WLM and there was only a modest decline of ERR/WLM with increasing time since exposure. |
format | Text |
id | pubmed-2360564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23605642009-09-10 Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 Grosche, B Kreuzer, M Kreisheimer, M Schnelzer, M Tschense, A Br J Cancer Epidemiology From 1946 to 1990 extensive uranium mining was conducted in the southern parts of the former German Democratic Republic. The overall workforce included several 100 000 individuals. A cohort of 59 001 former male employees of the Wismut Company was established, forming a large retrospective uranium miners' cohort for the time period 1946–1998. Mean duration of follow-up was 30.5 years with a total of 1 801 630 person-years. Loss to follow-up was low at 5.3%. Of the workers, 16 598 (28.1%) died during the study period. Based on 2388 lung cancer deaths, the radon-related lung cancer risk is evaluated. The excess relative risk (ERR) per working level month (WLM) was estimated as 0.21% (95% CI: 0.18–0.24). It was dependent on time since exposure and on attained age. The highest ERR/WLM was observed 15–24 years after exposure and in the youngest age group (<55 years of age). While a strong inverse exposure-rate effect was detected for high exposures, no significant association was detected at exposures below 100 WLM. Excess relative risk /WLM was not modified by duration of exposure. The results would indicate the need to re-estimate the effects of risk modifying factors in current risk models as duration of exposure did not modify the ERR/WLM and there was only a modest decline of ERR/WLM with increasing time since exposure. Nature Publishing Group 2006-11-06 2006-10-17 /pmc/articles/PMC2360564/ /pubmed/17043686 http://dx.doi.org/10.1038/sj.bjc.6603403 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Grosche, B Kreuzer, M Kreisheimer, M Schnelzer, M Tschense, A Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 |
title | Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 |
title_full | Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 |
title_fullStr | Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 |
title_full_unstemmed | Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 |
title_short | Lung cancer risk among German male uranium miners: a cohort study, 1946–1998 |
title_sort | lung cancer risk among german male uranium miners: a cohort study, 1946–1998 |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360564/ https://www.ncbi.nlm.nih.gov/pubmed/17043686 http://dx.doi.org/10.1038/sj.bjc.6603403 |
work_keys_str_mv | AT groscheb lungcancerriskamonggermanmaleuraniumminersacohortstudy19461998 AT kreuzerm lungcancerriskamonggermanmaleuraniumminersacohortstudy19461998 AT kreisheimerm lungcancerriskamonggermanmaleuraniumminersacohortstudy19461998 AT schnelzerm lungcancerriskamonggermanmaleuraniumminersacohortstudy19461998 AT tschensea lungcancerriskamonggermanmaleuraniumminersacohortstudy19461998 |