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(18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response
To determine whether [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) could predict the pathological response in oesophageal cancer after only the first week of neoadjuvant chemoradiation. Thirty-two patients with localised oesophageal cancer had a pretreatment PET scan and a repeat...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360565/ https://www.ncbi.nlm.nih.gov/pubmed/17024121 http://dx.doi.org/10.1038/sj.bjc.6603412 |
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author | Gillham, C M Lucey, J A Keogan, M Duffy, G J Malik, V Raouf, A A O'Byrne, K Hollywood, D Muldoon, C Reynolds, J V |
author_facet | Gillham, C M Lucey, J A Keogan, M Duffy, G J Malik, V Raouf, A A O'Byrne, K Hollywood, D Muldoon, C Reynolds, J V |
author_sort | Gillham, C M |
collection | PubMed |
description | To determine whether [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) could predict the pathological response in oesophageal cancer after only the first week of neoadjuvant chemoradiation. Thirty-two patients with localised oesophageal cancer had a pretreatment PET scan and a repeat after the first week of chemoradiation. The change in mean maximum standardised uptake value (SUV) and volume of metabolically active tissue (MTV) was compared with the tumour regression grade (TRG) in the final histology. Those who achieved a TRG of 1 and 2 were deemed responders and 3–5 nonresponders. In the responders (28%), the SUV fell from 12.6 (±6.3) to 8.1 (±2.9) after 1 week of chemoradiation (P=0.070). In nonresponders (72%), the results were 9.7 (±5.4) and 7.1 (±3.8), respectively (P=0.003). The MTV in responders fell from 36.6 (±22.7) to 22.3 (±10.4) cm(3) (P=0.180), while in nonresponders, this fell from 35.9 (±36.7) to 31.9 (±52.7) cm(3) (P=0.405). There were no significant differences between responders and nonresponders. The hypothesis that early repeat FDG-PET scanning may predict histomorphologic response was not proven. This may reflect an inflammatory effect of radiation that obscures tumour-specific metabolic changes at this time. This assessment may have limited application in predicting response to multimodal regimens for oesophageal cancer. |
format | Text |
id | pubmed-2360565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23605652009-09-10 (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response Gillham, C M Lucey, J A Keogan, M Duffy, G J Malik, V Raouf, A A O'Byrne, K Hollywood, D Muldoon, C Reynolds, J V Br J Cancer Clinical Study To determine whether [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) could predict the pathological response in oesophageal cancer after only the first week of neoadjuvant chemoradiation. Thirty-two patients with localised oesophageal cancer had a pretreatment PET scan and a repeat after the first week of chemoradiation. The change in mean maximum standardised uptake value (SUV) and volume of metabolically active tissue (MTV) was compared with the tumour regression grade (TRG) in the final histology. Those who achieved a TRG of 1 and 2 were deemed responders and 3–5 nonresponders. In the responders (28%), the SUV fell from 12.6 (±6.3) to 8.1 (±2.9) after 1 week of chemoradiation (P=0.070). In nonresponders (72%), the results were 9.7 (±5.4) and 7.1 (±3.8), respectively (P=0.003). The MTV in responders fell from 36.6 (±22.7) to 22.3 (±10.4) cm(3) (P=0.180), while in nonresponders, this fell from 35.9 (±36.7) to 31.9 (±52.7) cm(3) (P=0.405). There were no significant differences between responders and nonresponders. The hypothesis that early repeat FDG-PET scanning may predict histomorphologic response was not proven. This may reflect an inflammatory effect of radiation that obscures tumour-specific metabolic changes at this time. This assessment may have limited application in predicting response to multimodal regimens for oesophageal cancer. Nature Publishing Group 2006-11-06 2006-10-03 /pmc/articles/PMC2360565/ /pubmed/17024121 http://dx.doi.org/10.1038/sj.bjc.6603412 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Study Gillham, C M Lucey, J A Keogan, M Duffy, G J Malik, V Raouf, A A O'Byrne, K Hollywood, D Muldoon, C Reynolds, J V (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
title | (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
title_full | (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
title_fullStr | (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
title_full_unstemmed | (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
title_short | (18)FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
title_sort | (18)fdg uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360565/ https://www.ncbi.nlm.nih.gov/pubmed/17024121 http://dx.doi.org/10.1038/sj.bjc.6603412 |
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