Targeting sphingosine-1-phosphate for cancer therapy

This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like S1P, can t...

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Detalles Bibliográficos
Autor principal: Sabbadini, R A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360571/
https://www.ncbi.nlm.nih.gov/pubmed/17024123
http://dx.doi.org/10.1038/sj.bjc.6603400
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author Sabbadini, R A
author_facet Sabbadini, R A
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description This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like S1P, can themselves be targets for rational drug design, thereby opening up an entire class of lipidomic-based therapeutics for oncology and other human diseases.
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spelling pubmed-23605712009-09-10 Targeting sphingosine-1-phosphate for cancer therapy Sabbadini, R A Br J Cancer Minireview This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like S1P, can themselves be targets for rational drug design, thereby opening up an entire class of lipidomic-based therapeutics for oncology and other human diseases. Nature Publishing Group 2006-11-06 2006-10-03 /pmc/articles/PMC2360571/ /pubmed/17024123 http://dx.doi.org/10.1038/sj.bjc.6603400 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Sabbadini, R A
Targeting sphingosine-1-phosphate for cancer therapy
title Targeting sphingosine-1-phosphate for cancer therapy
title_full Targeting sphingosine-1-phosphate for cancer therapy
title_fullStr Targeting sphingosine-1-phosphate for cancer therapy
title_full_unstemmed Targeting sphingosine-1-phosphate for cancer therapy
title_short Targeting sphingosine-1-phosphate for cancer therapy
title_sort targeting sphingosine-1-phosphate for cancer therapy
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360571/
https://www.ncbi.nlm.nih.gov/pubmed/17024123
http://dx.doi.org/10.1038/sj.bjc.6603400
work_keys_str_mv AT sabbadinira targetingsphingosine1phosphateforcancertherapy

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