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The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours
It is thought that the time interval between the antecedent pregnancy and diagnosis of gestational trophoblastic tumours (GTTs) may influence the outcome of these patients. In this study, we investigate the significance of this time interval. Multivariate analysis was used to investigate if the time...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360575/ https://www.ncbi.nlm.nih.gov/pubmed/17031399 http://dx.doi.org/10.1038/sj.bjc.6603416 |
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author | Powles, T Young, A Sammit, A Stebbing, J Short, D Bower, M Savage, P M Seckl, M J Schmid, P |
author_facet | Powles, T Young, A Sammit, A Stebbing, J Short, D Bower, M Savage, P M Seckl, M J Schmid, P |
author_sort | Powles, T |
collection | PubMed |
description | It is thought that the time interval between the antecedent pregnancy and diagnosis of gestational trophoblastic tumours (GTTs) may influence the outcome of these patients. In this study, we investigate the significance of this time interval. Multivariate analysis was used to investigate if the time interval was of prognostic significance from our cohort of 241 high-risk patients with GTT. Subsequent cutpoint analysis was used to determine an optimal cutpoint for the interval covariate. The outcome of these patients was plotted according to the Kaplan–Meier method. The time interval was of prognostic significance on multivariate analysis. A period of greater than 2.8 years after pregnancy was found to be of most significance. The 5-year overall survival was 62.0% (95% CI: 47–76%) for greater than 2.8 years vs 94% (95% CI: 91–97%) for less than 2.8 years (P<0.001). Multivariate analysis showed the presence of liver metastasis and the number of metastasis was also of prognostic importance. The interval between antecedent pregnancy and diagnosis in high-risk GTT is of prognostic significance. This gives some insight into the pathogenesis of the disease. |
format | Text |
id | pubmed-2360575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23605752009-09-10 The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours Powles, T Young, A Sammit, A Stebbing, J Short, D Bower, M Savage, P M Seckl, M J Schmid, P Br J Cancer Short Communication It is thought that the time interval between the antecedent pregnancy and diagnosis of gestational trophoblastic tumours (GTTs) may influence the outcome of these patients. In this study, we investigate the significance of this time interval. Multivariate analysis was used to investigate if the time interval was of prognostic significance from our cohort of 241 high-risk patients with GTT. Subsequent cutpoint analysis was used to determine an optimal cutpoint for the interval covariate. The outcome of these patients was plotted according to the Kaplan–Meier method. The time interval was of prognostic significance on multivariate analysis. A period of greater than 2.8 years after pregnancy was found to be of most significance. The 5-year overall survival was 62.0% (95% CI: 47–76%) for greater than 2.8 years vs 94% (95% CI: 91–97%) for less than 2.8 years (P<0.001). Multivariate analysis showed the presence of liver metastasis and the number of metastasis was also of prognostic importance. The interval between antecedent pregnancy and diagnosis in high-risk GTT is of prognostic significance. This gives some insight into the pathogenesis of the disease. Nature Publishing Group 2006-11-06 2006-10-10 /pmc/articles/PMC2360575/ /pubmed/17031399 http://dx.doi.org/10.1038/sj.bjc.6603416 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Short Communication Powles, T Young, A Sammit, A Stebbing, J Short, D Bower, M Savage, P M Seckl, M J Schmid, P The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
title | The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
title_full | The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
title_fullStr | The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
title_full_unstemmed | The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
title_short | The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
title_sort | significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360575/ https://www.ncbi.nlm.nih.gov/pubmed/17031399 http://dx.doi.org/10.1038/sj.bjc.6603416 |
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