Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer

We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation...

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Autores principales: Van den Eynden, G G, Van der Auwera, I, Van Laere, S J, Huygelen, V, Colpaert, C G, van Dam, P, Dirix, L Y, Vermeulen, P B, Van Marck, E A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360596/
https://www.ncbi.nlm.nih.gov/pubmed/17088912
http://dx.doi.org/10.1038/sj.bjc.6603443
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author Van den Eynden, G G
Van der Auwera, I
Van Laere, S J
Huygelen, V
Colpaert, C G
van Dam, P
Dirix, L Y
Vermeulen, P B
Van Marck, E A
author_facet Van den Eynden, G G
Van der Auwera, I
Van Laere, S J
Huygelen, V
Colpaert, C G
van Dam, P
Dirix, L Y
Vermeulen, P B
Van Marck, E A
author_sort Van den Eynden, G G
collection PubMed
description We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P<0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular.
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spelling pubmed-23605962009-09-10 Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer Van den Eynden, G G Van der Auwera, I Van Laere, S J Huygelen, V Colpaert, C G van Dam, P Dirix, L Y Vermeulen, P B Van Marck, E A Br J Cancer Molecular Diagnostics We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P<0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular. Nature Publishing Group 2006-11-20 2006-10-31 /pmc/articles/PMC2360596/ /pubmed/17088912 http://dx.doi.org/10.1038/sj.bjc.6603443 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Van den Eynden, G G
Van der Auwera, I
Van Laere, S J
Huygelen, V
Colpaert, C G
van Dam, P
Dirix, L Y
Vermeulen, P B
Van Marck, E A
Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
title Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
title_full Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
title_fullStr Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
title_full_unstemmed Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
title_short Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
title_sort induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360596/
https://www.ncbi.nlm.nih.gov/pubmed/17088912
http://dx.doi.org/10.1038/sj.bjc.6603443
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