Are microRNAs located in genomic regions associated with cancer?

We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy n...

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Autores principales: Lamy, P, Andersen, C L, Dyrskjot, L, Torring, N, Orntoft, T, Wiuf, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360608/
https://www.ncbi.nlm.nih.gov/pubmed/17003783
http://dx.doi.org/10.1038/sj.bjc.6603381
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author Lamy, P
Andersen, C L
Dyrskjot, L
Torring, N
Orntoft, T
Wiuf, C
author_facet Lamy, P
Andersen, C L
Dyrskjot, L
Torring, N
Orntoft, T
Wiuf, C
author_sort Lamy, P
collection PubMed
description We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.
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spelling pubmed-23606082009-09-10 Are microRNAs located in genomic regions associated with cancer? Lamy, P Andersen, C L Dyrskjot, L Torring, N Orntoft, T Wiuf, C Br J Cancer Genetics and Genomics We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression. Nature Publishing Group 2006-11-20 2006-09-26 /pmc/articles/PMC2360608/ /pubmed/17003783 http://dx.doi.org/10.1038/sj.bjc.6603381 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Lamy, P
Andersen, C L
Dyrskjot, L
Torring, N
Orntoft, T
Wiuf, C
Are microRNAs located in genomic regions associated with cancer?
title Are microRNAs located in genomic regions associated with cancer?
title_full Are microRNAs located in genomic regions associated with cancer?
title_fullStr Are microRNAs located in genomic regions associated with cancer?
title_full_unstemmed Are microRNAs located in genomic regions associated with cancer?
title_short Are microRNAs located in genomic regions associated with cancer?
title_sort are micrornas located in genomic regions associated with cancer?
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360608/
https://www.ncbi.nlm.nih.gov/pubmed/17003783
http://dx.doi.org/10.1038/sj.bjc.6603381
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