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Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins

Apoptosis is a physiological form of cell death important in normal processes such as morphogenesis and the functioning of the immune system. In addition, defects in the apoptotic process play a major role in a number of important areas of disease, such as autoimmune diseases and cancer. DNA-damage-...

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Autores principales: Camplejohn, R S, Hodgson, S, Carter, N, Kato, B S, Spector, T D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360659/
https://www.ncbi.nlm.nih.gov/pubmed/16819540
http://dx.doi.org/10.1038/sj.bjc.6603257
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author Camplejohn, R S
Hodgson, S
Carter, N
Kato, B S
Spector, T D
author_facet Camplejohn, R S
Hodgson, S
Carter, N
Kato, B S
Spector, T D
author_sort Camplejohn, R S
collection PubMed
description Apoptosis is a physiological form of cell death important in normal processes such as morphogenesis and the functioning of the immune system. In addition, defects in the apoptotic process play a major role in a number of important areas of disease, such as autoimmune diseases and cancer. DNA-damage-induced apoptosis plays a vital role in the maintenance of genomic stability by the removal of damaged cells. Previous studies of the apoptotic response (AR) to radiation-induced DNA damage of lymphoid cells from individuals carrying germline TP53 mutations have demonstrated a defective AR compared with normal controls. We have also previously demonstrated that AR is reduced as individuals age. Results from the current study on 108 twins aged 18–80 years confirm these earlier findings that the AR of lymphoid cells to DNA damage is significantly reduced with increasing age. In addition this twin study shows, for the first time, that DNA-damage-induced AR has a strong degree of heritability of 81% (95% confidence interval 67–89%). The vital role of DNA-damage-induced apoptosis in maintaining genetic stability, its relationship with age and its strong heritability underline the importance of this area of biology and suggest areas for further study.
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spelling pubmed-23606592009-09-10 Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins Camplejohn, R S Hodgson, S Carter, N Kato, B S Spector, T D Br J Cancer Molecular Diagnostics Apoptosis is a physiological form of cell death important in normal processes such as morphogenesis and the functioning of the immune system. In addition, defects in the apoptotic process play a major role in a number of important areas of disease, such as autoimmune diseases and cancer. DNA-damage-induced apoptosis plays a vital role in the maintenance of genomic stability by the removal of damaged cells. Previous studies of the apoptotic response (AR) to radiation-induced DNA damage of lymphoid cells from individuals carrying germline TP53 mutations have demonstrated a defective AR compared with normal controls. We have also previously demonstrated that AR is reduced as individuals age. Results from the current study on 108 twins aged 18–80 years confirm these earlier findings that the AR of lymphoid cells to DNA damage is significantly reduced with increasing age. In addition this twin study shows, for the first time, that DNA-damage-induced AR has a strong degree of heritability of 81% (95% confidence interval 67–89%). The vital role of DNA-damage-induced apoptosis in maintaining genetic stability, its relationship with age and its strong heritability underline the importance of this area of biology and suggest areas for further study. Nature Publishing Group 2006-08-21 2006-07-04 /pmc/articles/PMC2360659/ /pubmed/16819540 http://dx.doi.org/10.1038/sj.bjc.6603257 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Camplejohn, R S
Hodgson, S
Carter, N
Kato, B S
Spector, T D
Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
title Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
title_full Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
title_fullStr Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
title_full_unstemmed Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
title_short Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
title_sort heritability of dna-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360659/
https://www.ncbi.nlm.nih.gov/pubmed/16819540
http://dx.doi.org/10.1038/sj.bjc.6603257
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