Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

Cellular senescence, the irreversible proliferative arrest seen in somatic cells after a limited number of divisions, is considered a crucial barrier to cancer, but direct evidence for this in vivo was lacking until recently. The best-known form of human cell senescence is attributed to telomere sho...

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Detalles Bibliográficos
Autores principales: Gray-Schopfer, V C, Cheong, S C, Chong, H, Chow, J, Moss, T, Abdel-Malek, Z A, Marais, R, Wynford-Thomas, D, Bennett, D C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360676/
https://www.ncbi.nlm.nih.gov/pubmed/16880792
http://dx.doi.org/10.1038/sj.bjc.6603283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360676/
https://www.ncbi.nlm.nih.gov/pubmed/16880792
http://dx.doi.org/10.1038/sj.bjc.6603283

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