Association of decreased mitochondrial DNA content with ovarian cancer progression

Mitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or tumour stages. However, the average mtDNA co...

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Autores principales: Wang, Y, Liu, V W S, Xue, W C, Cheung, A N Y, Ngan, H Y S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360719/
https://www.ncbi.nlm.nih.gov/pubmed/17047655
http://dx.doi.org/10.1038/sj.bjc.6603377
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author Wang, Y
Liu, V W S
Xue, W C
Cheung, A N Y
Ngan, H Y S
author_facet Wang, Y
Liu, V W S
Xue, W C
Cheung, A N Y
Ngan, H Y S
author_sort Wang, Y
collection PubMed
description Mitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P=0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in type II carcinomas (P=0.019). Change in mtDNA content might be an important genetic event in the progression of ovarian carcinomas.
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spelling pubmed-23607192009-09-10 Association of decreased mitochondrial DNA content with ovarian cancer progression Wang, Y Liu, V W S Xue, W C Cheung, A N Y Ngan, H Y S Br J Cancer Short Communication Mitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P=0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in type II carcinomas (P=0.019). Change in mtDNA content might be an important genetic event in the progression of ovarian carcinomas. Nature Publishing Group 2006-10-23 2006-10-03 /pmc/articles/PMC2360719/ /pubmed/17047655 http://dx.doi.org/10.1038/sj.bjc.6603377 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Wang, Y
Liu, V W S
Xue, W C
Cheung, A N Y
Ngan, H Y S
Association of decreased mitochondrial DNA content with ovarian cancer progression
title Association of decreased mitochondrial DNA content with ovarian cancer progression
title_full Association of decreased mitochondrial DNA content with ovarian cancer progression
title_fullStr Association of decreased mitochondrial DNA content with ovarian cancer progression
title_full_unstemmed Association of decreased mitochondrial DNA content with ovarian cancer progression
title_short Association of decreased mitochondrial DNA content with ovarian cancer progression
title_sort association of decreased mitochondrial dna content with ovarian cancer progression
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360719/
https://www.ncbi.nlm.nih.gov/pubmed/17047655
http://dx.doi.org/10.1038/sj.bjc.6603377
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