NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines

HIV-1 protease inhibitor (PI), nelfinavir (NFV) induced growth arrest and apoptosis of NCI-H460 and -H520, A549, EBC-1 and ABC-1 non-small-cell lung cancer (NSCLC) cells in association with upregulation of p21(waf1), p27 (kip1) and p53, and downregulation of Bcl-2 and matrix metalloproteinase (MMP)-...

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Detalles Bibliográficos
Autores principales: Yang, Y, Ikezoe, T, Nishioka, C, Bandobashi, K, Takeuchi, T, Adachi, Y, Kobayashi, M, Takeuchi, S, Koeffler, H P, Taguchi, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360758/
https://www.ncbi.nlm.nih.gov/pubmed/17133272
http://dx.doi.org/10.1038/sj.bjc.6603435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360758/
https://www.ncbi.nlm.nih.gov/pubmed/17133272
http://dx.doi.org/10.1038/sj.bjc.6603435

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